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Wednesday, November 25, 2020 | History

2 edition of Effects of early postnatal tamoxifen administration on nonreproductive behaviors in female mice found in the catalog.

Effects of early postnatal tamoxifen administration on nonreproductive behaviors in female mice

Deborah Louise Silver

Effects of early postnatal tamoxifen administration on nonreproductive behaviors in female mice

  • 62 Want to read
  • 21 Currently reading

Published .
Written in English

    Subjects:
  • Rats -- Behavior.,
  • Rats -- Physiology.,
  • Tamoxifen.

  • Edition Notes

    Statementby Deborah Louise Silver.
    Series[Master"s theses / University Center at Binghamton, State University of New York -- no. 1159], Master"s theses (State University of New York at Binghamton) -- no. 1159.
    The Physical Object
    Pagination44, [6] leaves :
    Number of Pages44
    ID Numbers
    Open LibraryOL22143393M

    For some women with breast cancer, taking adjuvant tamoxifen (Nolvadex®) for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug for only 5 years, according to the results of a large international clinical trial.. The findings from the ATLAS trial—presented at the San Antonio Breast Cancer Symposium (SABCS) and published. Thus, the prenatal administration of bisphenol A to pregnant mice and postnatal administration to offspring until postnatal day 15 produces anxiolytic behavior in elevated plus-maze and open field tests. Interestingly, this behavior has been related to a significant decrease of DAT in striatum and NMDA receptor in frontal cortex.


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Effects of early postnatal tamoxifen administration on nonreproductive behaviors in female mice by Deborah Louise Silver Download PDF EPUB FB2

Postnatal (P1–3) loss of Nf1 in PlpCre;Nf1fl/fl mice causes early and later mortality. To test whether loss of Nf1 within postnatal cells elicits tumors in vivo, we chose a tamoxifen-inducible PlpCre driver.

Survival was monitored after postnatal tamoxifen exposure within PlpCre mice and showed two phases of mortality (Fig. 1A; P Cited by: The patient became pregnant while taking tamoxifen for 6 months in She discontinued tamoxifen when 4 weeks pregnant and had a voluntary medical abortion at 6 weeks gestation.

She subsequently continued tamoxifen treatment. Tamoxifen is a non-steroidal anti-estrogen agent used in the treatment of ER-positive breast by: 7.

Abstract. Historically, Tamoxifen has been synthesized as an antiestrogen by Harper and Walpole (). However, this substance showed some estrogenic effects when examined in laboratory animals: a complete estrogen agonist in the chick oviduct (Sutherland et al., ), a partial agonist with antiestrogenic activity in the immature and ovariectomized rat (Harper and Walpole, ; Jordan and Cited by:   Tamoxifen's Mental Side Effects Are Real: Study.

They found one drug, currently called AZD, that protected the brain cells of mice against tamoxifen in their own study. between intact male and female mice to show rewarding or aversive properties of TMX (unpublished data). A previous study reported no differences in spatial working memory between intact male and female rats (Healy et al.

In addition, some studies have shown that ovariectomy of female mice and rats can affect cognitive performance (El. Experimental animals. Young adult wild-type (WT) C57BL/6J mice and mice homozygous for the Pde6b rd10 (rd10) mutation were obtained from The Jackson Laboratory.

Postnatal rd10 mice (21–50 d of age) and young adult WT mice (2–3 months of age) of both sexes were raised in cyclic light (∼ lux, h) in a National Institutes of Health animal facility.

"I noticed many of these men were stopping tamoxifen therapy early, and the side effects seemed to be different from those generally reported in women." Side Effects Different From Women Researchers analyzed the medical records of 64 male breast cancer patients treated at.

The possible role of personality patterns and psychosocial factors in breast cancer has been studied extensively, through both human and animal experiments. The data are conflicting, and the conclusions controversial. This review will serve two purposes. First, we present evidence that behavioral patterns most commonly linked to breast cancer risk are at least partly regulated by estrogens.

Background Some studies suggest that the clinical parameter “amenorrhea” is insufficient to define the menopausal status of women treated with chemotherapy or tamoxifen.

In this study, we investigated and compared the ovarian function defined either by clinical or biological parameters in pre-menopausal breast cancer patients treated with tamoxifen administered as adjuvant therapy. Angela, a Pink Hope Community Member who was diagnosed with breast cancer at 22, provides an overview of the drug Tamoxifen and shares her struggle with managing the side effects of taking this drug.

Tamoxifen tamoxifen What can I write about this drug that has caused me personally so much anguish and turned my hormones upside down – five years is a long time to be taking this medication.

Objective: Tamoxifen is used widely as adjuvant therapy for breast cancer in postmenopausal women. Our objective was to evaluate the effects of tamoxifen on serum estradiol and the endometrium of postmenopausal patients with breast cancer attending the Oncology Clinic at Belfast City Hospital.

Design: A prospective study of 48 selected patients with breast cancer on maintenance tamoxifen. Hi Sean, I have used the brainbow-CreERT2 inducible mice in embryonic and postnatal stages (giving fancy and individually coloured neurons). I have tried applying tamoxifen pretty much any time. Affiliative behaviors like sniffing, contact, and allogrooming generally increase with age in outbred male and female CD-1 mice from P23 to P47, but this effect depends on sex and previous social isolation.

Anogenital sniffing is the only behavior that shows an adolescent peak similar to patterns observed in rats, and is highest between P In the present study, we investigated the effects of E(2) and P (alone or together) on the nitrergic system of gonadectomized female mice, following a timing of administration that emulates the.

Introduction. Estradiol (E2) in males is produced from testosterone by aromatization, and is involved in various biological functions (Wibowo et al., ; Wibowo & Wassersug, ).E2 exerts its effects by binding to estrogen receptors (ERs), and administration of the selective estrogen receptor modulator (SERM) tamoxifen can alter estrogenic responses in the body through competitive binding.

Administration of high doses of tamoxifen can rapidly induce abortion in pregnant mice but this can be partially overcome by progesterone co-administration. However, administration of tamoxifen to pregnant mice early in pregnancy may have potentially lethal effects on the mother independently of.

For women with ER-positive disease, continuing tamoxifen to 10 years rather than stopping at 5 years produces a further reduction in recurrence and mortality, particularly after year These results, taken together with results from previous trials of 5 years of tamoxifen treatment versus none, suggest that 10 years of tamoxifen treatment can approximately halve breast cancer mortality.

The pharmacokinetics of Tamoxifen and N-desmethyl Tamoxifen were characterized using a population pharmacokinetic analysis with sparse samples per patient obtained from 27 female pediatric patients aged 2 to 10 years enrolled in a study designed to evaluate the safety, efficacy, and pharmacokinetics of Tamoxifen citrate in treating McCune.

Tamoxifen is a hazardous substance. Review the MSDS, wear appropriate PPE, and, if possible, house mice in disposable pens in a separate animal room for the duration of injections.

Procedure: Dissolve tamoxifen (Sigma‐Aldrich) in corn oil at a concentration of 20 mg/ml by shaking overnight at 37°C. Purpose Five years of adjuvant tamoxifen therapy for estrogen receptor (ER) –positive breast cancer is more effective than 2 years of use.

However, information on tamoxifen discontinuation is scanty. We sought to identify predictors of tamoxifen discontinuation among older women with breast cancer. Patients and Methods Within six health care delivery systems, we identified women ≥ 65 years.

The effect of sequential treatment on MCF-7Ca breast tumors that progressed on exemestane or tamoxifen alone or the combination of exemestane and tamoxifen in ovariectomized female athymic mice., mice treated with tamoxifen ( μg/day) as first-line therapy were switched after 9 weeks to treatment with exemestane ( μg/day) for 3 weeks to.

ATLANTA — Tamoxifen, the most widely prescribed drug for treating and preventing breast cancer in women, increases anxiety behaviors in female rhesus macaques, according to a study conducted at the Yerkes National Primate Research Center of Emory University by Yerkes, Emory and Atlanta-based Center for Behavioral Neuroscience (CBN) researchers.

sants and resistant to treatment, but the symptoms improved after interruption of tamoxifen. This observation suggests that tamoxifen may aggravate depression in severe and refractory conditions. Key words Depression, Tamoxifen, Estrogen, Breast cancer The Case Patient: Female, 63 years old.

Genetic factors: Mother committed suicide. Dose effect of ZK on lordosis behavior in adult female mice. Following 3 pre-tests, 5 h before the 4th test, adult female mice were injected s.c. with either (A) 6 mg/kg of ZK (ZK 6) or (B) 9 mg/kg (ZK 9) or (C)12 mg/kg of RU (RU 12). Then, a fifth test was performed with just estradiol and progesterone.

They demonstrated that tamoxifen prevented gastric cancer in male mice infected with H. pylori, suggesting that tamoxifen may act as an agonist in this context.

They also suggested that this prevention of gastric cancer by both 17β-estradiol and tamoxifen may be due to a pro-estrogen effect, decreasing the inflammatory response and oncogenic.

Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer).

Postnatal (P1–3) loss of Nf1 in PlpCre;Nf1fl/fl mice causes early and later mortality To test whether loss of Nf1 within postnatal cells elicits tumors in vivo, we chose a tamoxifen-inducible PlpCre driver.

Survival was monitored after postnatal (1–3) tamoxifen expo-sure within PlpCre mice and showed two phases of mortality (Fig. 1A; P. Summary: Purpose: Estrogens have neuroprotective effects in ischemia, stroke, and other conditions leading to neuronal cell death (e.g., Alzheimer's disease).The present study examined whether estrogens may have neuroprotective effects after seizures.

Methods: The kainic acid model was used to determine if estrogens protect hippocampal cells after status epilepticus in adult female rats.

There are no data that address whether tamoxifen is excreted into human milk; direct neonatal exposure of tamoxifen to mice and rats (not via breast milk) produced 1) reproductive tract lesions in female rodents (similar to those seen in humans after intrauterine exposure to diethylstilbestrol) and 2) functional defects of the reproductive.

The potential side effects and fertility impact of tamoxifen lead some young women to stop, or never start, the treatment despite its ability to help prevent cancer from coming back, a study shows.

Background. Tamoxifen is a hormonal therapy given after treatment for hormone receptor-positive breast reduces the risk of recurrence, the return of cancer. Tamoxifen (Breast) UM Rogel Cancer Center Tamoxifen Hormonal Therapy 3 • Tamoxifen increases growth of clotting proteins in the liver, just like estrogen.

So, women who take tamoxifen have a slightly higher risk of getting a blood clot in the leg (called deep vein thrombosis), which can be very. Tamoxifen, a selective estrogen receptor modulator, is widely used in research and clinically in patients. We find that treatment of normal mice with a single ≥3 mg/20 g body weight dose of tamoxifen leads to apoptosis of >90% of all gastric parietal cells (PCs) and metaplasia of zymogenic chief cells within 3 days.

Remarkably, gastric histology returns to nearly normal by 3 weeks. Attention should be paid to abnormalities in female genital organs exposed to estrogenic endocrine disruptors during fetal and early postnatal development in mammals including humans.

INTRODUCTION Perinatal sex-hormone exposure has been found to induce lesions in the vagina, cervix and uterus in female mice (Dunn and Green, ; Takasugi and. Tamoxifen is an anti-estrogenic drug that is widely used for endocrine-dependent breast cancer as adjuvant hormonal therapy, and its use has been reported to be frequently associated with high levels of serum estradiol.

Since the population of premenopausal women receiving tamoxifen therapy is growing in Japan, we retrospectively analyzed the incidence of ovarian hyperstimulation by tamoxifen.

R.E. Johnston, J. delBarco-Trillo, in Hormones, Brain and Behavior (Second Edition), Hormonal control of scent-marking behavior.

Male scent-marking behavior is generally stimulated by androgens and by odors of other males and, in some species, by odors of females as well (Yahr, ).In adult male hamsters, castration reduces scent marking toward cues from other males and.

Tamoxifen is a prescription drug. It comes as an oral tablet and an oral solution. Tamoxifen oral tablet is only available as a generic drug.

Generic drugs usually cost. Most of the women who stopped taking hormonal therapy early -- about 83% -- said they stopped taking the medicine because of side effects. Women who took Femara then tamoxifen or tamoxifen then Femara were more likely to stop taking hormonal therapy early.

Joint pain was the most common reason women stopped taking Femara early. Tamoxifen works on the whole body (known as systemic treatment) and blocks the effects of oestrogen on these receptors. This helps to stop oestrogen from encouraging any breast cancer cells to grow.

If oestrogen receptors are not found the breast cancer is known as oestrogen receptor negative or ER. Side effects: weight gain, chronic fatigue, mood swings, low body temp, hair falling out, joint and muscle pain and trouble sleeping.

Background: I am a 35 y/o female, double mastectomy in Feb for breast cancer, no chemo, no radiation. Have to be on the tamoxifen for 5 years.

Continued. It wasn't until the s that researchers discovered tamoxifen's ability to suppress breast cancer growth -- and the drug became a drug of choice in breast cancer treatment and.

Description and Brand Names. Drug information provided by: IBM Micromedex US Brand Name. Nolvadex; Soltamox; Descriptions. Tamoxifen is used to treat certain types of breast cancer (eg, estrogen receptor-positive breast cancer that has spread to other parts of the body [metastatic], early stage estrogen receptor-positive breast cancer after surgery and radiation treatment).Thus tamoxifen treatment could potentially effect pubertal bone development.

The aim of this study was to assess the effects of tamoxifen on bone mineral density (BMD) and skeletal maturation when used for pubertal gynecomastia. We evaluated 20 boys with pubertal gynecomastia receiving tamoxifen for .For postmenopausal high-risk women, the guidelines recommend doctors discuss tamoxifen, Evista, and the aromatase inhibitor Aromasin (chemical name: exemestane) to reduce risk.

Both Evista and tamoxifen are approved by the U.S. Food and Drug Administration (FDA) to be used to prevent breast cancer in women who haven’t been diagnosed.